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Enantioselective direct functionalization of indoles by Pd/sulfoxide-phosphine-catalyzed N-allylic alkylation.

Authors
  • Chen, Li-Yan
  • Yu, Xiao-Ye
  • Chen, Jia-Rong
  • Feng, Bin
  • Zhang, Hong
  • Qi, Ying-Hua
  • Xiao, Wen-Jing
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Mar 20, 2015
Volume
17
Issue
6
Pages
1381–1384
Identifiers
DOI: 10.1021/acs.orglett.5b00077
PMID: 25738835
Source
Medline
License
Unknown

Abstract

A general and efficient Pd/sulfoxide-phosphine complex-catalyzed direct asymmetric N-allylic alkylation of indoles has been developed to allow for the preparation of various N-allylated indoles in generally good yields with excellent enantioselectivities. This catalytic system could also be extended to other N-containing heterocycles with good results.

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