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EMLA (lidocaine-prilocaine) cream for pain relief during hysterosalpingography: a systematic review and meta-analysis of randomised placebo-controlled trials.

Authors
  • Abu-Zaid, Ahmed1, 2
  • Baradwan, Saeed3
  • Abuzaid, Mohammed4
  • AlSghan, Rayan5
  • Alomar, Osama2, 6
  • Salem, Hany2, 6
  • Al-Badawi, Ismail A2, 6
  • 1 College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
  • 2 Department of Obstetrics and Gynecology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. , (Saudi Arabia)
  • 3 Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia. , (Saudi Arabia)
  • 4 Department of Obstetrics and Gynecology, King Fahad Medical City, Riyadh, Saudi Arabia. , (Saudi Arabia)
  • 5 Department of Obstetrics and Gynecology, Maternity and Children Hospital, Alkharj, Saudi Arabia. , (Saudi Arabia)
  • 6 Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. , (Saudi Arabia)
Type
Published Article
Journal
Human fertility (Cambridge, England)
Publication Date
Dec 01, 2023
Volume
26
Issue
5
Pages
978–986
Identifiers
DOI: 10.1080/14647273.2022.2040748
PMID: 35220865
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We systematically investigated the efficacy and safety of EMLA (5% lidocaine-prilocaine cream) versus placebo for pain relief among infertile patients undergoing hysterosalpingography (HSG). We screened four databases from inception until 25 November 2020. We included only randomised placebo-controlled trials (RCTs) and assessed their risk of bias. The main efficacy outcomes included safety and pain scores during the different stages of HSG. The pooled outcomes were summarised as mean difference (MD) with 95% confidence interval (CI). Three RCTs were included, comprising 258 patients (131 and 127 patients received EMLA and placebo, respectively). All RCTs revealed an overall low risk of bias. EMLA significantly reduced pain perception during cervical instrumentation of tenaculum and cannula (MD = -1.53, 95% CI [-2.59, -0.47], p = 0.005) and at 24 h after completion of HSG (MD = -1.30, 95% CI [-2.57, -0.03], p = 0.04). Despite EMLA decreased pain perception during the other procedural stages of HSG, the differences were not statistically significant compared with placebo. EMLA was safe and free of local and systemic adverse reactions. This meta-analysis advocates that topical application of 5% EMLA cream is safe and correlates with decreased pain perception during HSG, particularly during the cervical instrumentation step and at 24 h after HSG completion.

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