Affordable Access

Emetine myopathy: two case reports with pathobiochemical analysis.

Authors
  • Sugie, H
  • Russin, R
  • Verity, M A
Type
Published Article
Journal
Muscle & nerve
Publication Date
Jan 01, 1984
Volume
7
Issue
1
Pages
54–59
Identifiers
PMID: 6700630
Source
Medline
License
Unknown

Abstract

We report two female patients with a history of alcohol abuse presenting with proximal painful muscle weakness following aversion therapy with emetine hydrochloride. Muscle biopsy of Case 1 showed a reversible floccular-shaped loss of myosin ATPase and dehydrogenase, an accumulation of PAS positive material, and a normal lipid content. Repeat biopsy showed core change with no focal loss of myosin ATPase. In Case 2, muscle biopsy was taken 1 month after commencement of emetine therapy and revealed similar but milder changes to Case 1. Electron microscopy revealed Z-band streaming with a decrease or loss of mitochondria. Sarcotubular systems appeared normal in shape and size. Anaerobic glycolysis on homogenate from the initial biopsy of Case 1 showed generalized reduction of lactate formation, which returned to normal in the repeat biopsy.

Report this publication

Statistics

Seen <100 times