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The emerging role of microRNAs in asthma

Authors
  • Jiang, Xiaoying1, 2
  • 1 Xi’an Jiaotong University, Department of Genetics and Molecular Biology, School of Medicine, Xi’an, Shaanxi, 710061, China , Xi’an (China)
  • 2 University of Manchester, NIHR Translational Research Facility in Respiratory Medicine Group, School of Translational Medicine, Stopford Building, Manchester, M13 9PT, UK , Manchester (United Kingdom)
Type
Published Article
Journal
Molecular and Cellular Biochemistry
Publisher
Springer-Verlag
Publication Date
Mar 06, 2011
Volume
353
Issue
1-2
Pages
35–40
Identifiers
DOI: 10.1007/s11010-011-0771-z
Source
Springer Nature
Keywords
License
Yellow

Abstract

Asthma is a common chronic airways disease that worldwide affects people from all ethnic backgrounds. MicroRNAs (miRNAs) are small non-coding RNAs of 18–25 nucleotides that have been shown to regulate gene expression via the RNA interference pathway and found to play fundamental roles in diverse biological and pathological processes. Intriguingly, changes in the expression of several miRNAs are associated with development of asthma. In this review, we summarize the current understanding of the role of miRNAs in asthma to both better understand the pathogenesis of this disease and aid in the formulation of more effective therapeutic strategies.

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