Affordable Access

Access to the full text

Emerging role of long noncoding RNA-encoded micropeptides in cancer

Authors
  • Ye, Mujie1, 2
  • Zhang, Jingjing3
  • Wei, Meng1, 2
  • Liu, Baihui1, 2
  • Dong, Kuiran1, 2
  • 1 Children’s Hospital of Fudan University, No.399 Wanyuan Road, Minhang District, Shanghai, 201102, China , Shanghai (China)
  • 2 Ministry of Health, Shanghai, 201102, China , Shanghai (China)
  • 3 Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210001, China , Nanjing (China)
Type
Published Article
Journal
Cancer Cell International
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 16, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12935-020-01589-x
Source
Springer Nature
Keywords
License
Green

Abstract

Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain complex sequencing revealed that some short open reading frames of lncRNAs have micropeptide-coding potential. The resulting micropeptides have been shown to participate in N6-methyladenosine modification, tumor angiogenesis, cancer metabolism, and signal transduction. This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers.

Report this publication

Statistics

Seen <100 times