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The Emerging Role of Local Therapy in Metastatic Prostate Cancer

Authors
  • Sundahl, Nora1, 2
  • Tree, Alison1, 2
  • Parker, Chris1, 2
  • 1 Royal Marsden Hospital, Downs Road, Sutton, London, SM2 5PT, UK , Sutton (United Kingdom)
  • 2 Institute of Cancer Research, Sutton, London, UK , Sutton (United Kingdom)
Type
Published Article
Journal
Current Oncology Reports
Publisher
Springer-Verlag
Publication Date
Jan 20, 2020
Volume
22
Issue
1
Identifiers
DOI: 10.1007/s11912-020-0868-1
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of ReviewThis review summarizes the prospective clinical evidence regarding local therapy in metastatic prostate cancer.Recent FindingsThe phase 3 STAMPEDE trial showed that prostate radiotherapy confers a survival benefit for newly diagnosed patients with low volume metastatic hormone-sensitive prostate cancer (HSPC). No survival benefit was noted for those with high volume disease. A subsequent meta-analysis combining the data of the STAMPEDE trial with that of the HORRAD trial corroborated these findings. The phase 2 randomized STOMP trial investigated local treatment of metastases in patients with oligometastatic HSPC, and showed an improvement in hormone therapy–free survival.SummaryLocal prostate radiotherapy should be offered to patients with newly diagnosed low volume metastatic HSPC. Early clinical evidence suggests that local treatment to metastatic disease might be beneficial for patients with oligometastatic HSPC, but larger trials are awaited.

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