Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus.
Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany.
Institute of Biotechnology, Helsinki Institute for Life Science, University of Helsinki, 00014 Helsinki, Finland.
Centre for Integrative Biological Signalling Studies (CIBSS), 79104 Freiburg, Germany.
- Published Article
Cold Spring Harbor Perspectives in Biology
Cold Spring Harbor Laboratory
- Publication Date
Dec 07, 2020
Recent years have provided considerable insights into the dynamic nature of the cell nucleus, which is constantly reorganizing its genome, controlling its size and shape, as well as spatiotemporally orchestrating chromatin remodeling and transcription. Remarkably, it has become clear that the ancient and highly conserved cytoskeletal protein actin plays a crucial part in these processes. However, the underlying mechanisms, regulations, and properties of actin functions inside the nucleus are still not well understood. Here we summarize the diverse and distinct roles of monomeric and filamentous actin as well as the emerging roles for actin dynamics inside the nuclear compartment for genome organization and nuclear architecture. Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.
Report this publication
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 01/04/2021 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/33288541