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The emergence of genome architecture and zygotic genome activation

Authors
  • Vallot, Antoine1
  • Tachibana, Kikuë1, 2
  • 1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria
  • 2 Department of Totipotency, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany
Type
Published Article
Journal
Current Opinion in Cell Biology
Publisher
Elsevier
Publication Date
Jun 01, 2020
Volume
64
Pages
50–57
Identifiers
DOI: 10.1016/j.ceb.2020.02.002
PMID: 32220807
PMCID: PMC7374442
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

The fusion of two transcriptionally silent gametes, egg and sperm, generates a totipotent zygote that activates zygotic transcription to support further development. Although the molecular details of zygotic genome activation (ZGA) are not well understood in most species, an emerging concept is that one or more pioneer transcription factors trigger zygotic transcription. Concomitantly, extensive changes in 3D chromatin organization occur during development. In this review, we discuss recent advances in understanding when and how genome architecture emerges in early metazoan embryos, how the zygotic genome is activated, and how these events might be coordinated. We also highlight some of the unknowns that may be critical to address in the future.

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