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Embryotoxic effects of acrolein, methacrylates, guanidines and resorcinol on three day chicken embryos.

Authors
Type
Published Article
Journal
Acta pharmacologica et toxicologica
Publication Date
Volume
52
Issue
2
Pages
95–99
Identifiers
PMID: 6846027
Source
Medline

Abstract

Acrolein, four methacrylates, two guanidine compounds and resorcinol were tested for embryotoxicity on three day chicken embryos. The most potent chemical was acrolein, with the ED50 0.05 mumol per egg for the total effect, including deaths and malformations. The substances next in potency were N,N'-di-o-tolyl-guanidine and N,N-diphenylguanidine, with ED50 values 0.17 and 0.20 mumol per egg, respectively. Resorcinol and the methacrylates had ED50 values ranging from 2.4 to 22.0 mumol per egg. Acrolein, diphenylguanidine, tetrahydrofururylmethacrylate and trimethylolpropanetrimethacrylate caused the largest amounts of malformed embryos.

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