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Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads.

Authors
Type
Published Article
Journal
The Journal of antimicrobial chemotherapy
Publication Date
Volume
48
Issue
1
Pages
117–119
Identifiers
PMID: 11418521
Source
Medline
License
Unknown

Abstract

The in vitro release of vancomycin, teicoplanin, gentamicin and clindamycin from biodegradable calcium sulphate (CaSO(4)) carrier beads is described. All antibiotics showed prolonged release from the carrier beads, which was elevated during the first 24 h, with peak levels exceeding 2500 microg/bead. Doubling the antibiotic load of the beads revealed a more prolonged elution and a two-fold increase in antibiotic release. Local carrier-associated antibiotic treatment with CaSO(4) beads may prove to be effective in the management of chronic bone infections.

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