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Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger

  • Holm, Dorte Koefoed
  • Petersen, Lene Maj
  • Klitgaard, Andreas
  • Jarczynska, Zofia Dorota
  • Larsen, Thomas Ostenfeld
  • Mortensen, Uffe Hasbro
Publication Date
Jan 01, 2012
Online Research Database In Technology
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We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS). In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.

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