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Elimination of plasmids by new 4-quinolones.

Authors
  • J Weisser
  • B Wiedemann
Publication Date
Nov 01, 1985
Source
PMC
Keywords
License
Unknown

Abstract

Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa.

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