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Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Authors
  • Xie, Xiaodong1
  • Nie, Huifang1
  • Zhou, Yu1
  • Lian, Shu1
  • Mei, Hao1
  • Lu, Yusheng2
  • Dong, Haiyan1, 3
  • Li, Fengqiao1
  • Li, Tao1
  • Li, Bifei1
  • Wang, Jie1
  • Lin, Min1
  • Wang, Chaihung1
  • Shao, Jingwei1
  • Gao, Yu1
  • Chen, Jianming2
  • Xie, Fangwei4
  • Jia, Lee1, 2
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Dec 02, 2019
Volume
10
Issue
1
Identifiers
DOI: 10.1038/s41467-019-13316-w
Source
Springer Nature
License
Green

Abstract

Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate them via the hepatobiliary route.

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