Affordable Access

Elevated serum proinsulin in beta cell nesidioblastosis. Report of a case in a newborn.

Authors
  • Kühl, C
  • Hvorslev, V
  • Tygstrup, I
  • Lindkaer Jensen, S
Type
Published Article
Journal
Scandinavian journal of gastroenterology. Supplement
Publication Date
Jan 01, 1979
Volume
53
Pages
49–52
Identifiers
PMID: 225788
Source
Medline
License
Unknown

Abstract

A newborn infant with severe hypoglycaemia and nesidioblastosis was subjected to subtotal pancreatectomy without any sign of improvement. In spite of very low plasma levels of glucose (i.e. less than 1 mmol/l) plasma insulin concentrations were high (i.e. greater than 700 pmol/l). Plasma proinsulin was considerably enhanced comprising 43% of the total insulin immunoreactivity. Plasma glucagon concentrations were normal. Postoperatively normal to subnormal plasma glucose levels could only be maintained by treatment with frequent meals, diazoxide and intramuscular injections of a long-acting glucagon preparation. With time, signs of mental retardation became obvious.

Report this publication

Statistics

Seen <100 times