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Elevated serum levels of B-cell activating factor in pediatric renal transplant patients.

Authors
  • Lehnhardt, Anja1
  • Dunst, Franziska
  • van Husen, Michael
  • Loos, Sebastian
  • Oh, Jun
  • Eiermann, Thomas
  • Koch, Martina
  • Kemper, Markus J
  • 1 University Medical Center Hamburg-Eppendorf, Pediatric Nephrology, Martinistrasse 52, 20246 Hamburg, Germany. [email protected] , (Germany)
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Aug 01, 2012
Volume
27
Issue
8
Pages
1389–1395
Identifiers
DOI: 10.1007/s00467-012-2142-8
PMID: 22453734
Source
Medline
License
Unknown

Abstract

Serum BAFF concentrations were significantly elevated in pediatric RT patients. They correlated with decreased BAFF-R expression on CD19+ B-cells and impaired allograft function. Our findings of a dysregulated BAFF/BAFF-R axis may be of clinical relevance after renal transplantation and therefore underline the importance of further research into BAFF-dependent mechanisms.

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