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Elevated plasma nitrate in patients with crush syndrome caused by the Kobe earthquake.

Authors
Type
Published Article
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
269
Issue
2
Pages
137–145
Identifiers
PMID: 9526673
Source
Medline
License
Unknown

Abstract

We investigated the nitric oxide profile in the plasma of ten healthy controls and 29 patients hurt by the Kobe Earthquake. The levels of nitrite (NO2-) and nitrate (NO3-) were measured simultaneously by high-performance liquid chromatography (HPLC) with UV detection using the Griess reaction after the reduction of nitrate to nitrite. Arginine consumed in food or diet-derived nitrite had no effect on the plasma nitrite and nitrate contents of the healthy volunteers. Plasma nitrate was elevated in the crush syndrome patients; whereas neither nitrite nor nitrate was increased in patients with normal renal function. This finding suggests increased nitric oxide synthesis, decreased excretion of nitric oxide in the crush syndrome or both.

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