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Elevated plasma cryofibrinogen in patients with active inflammatory bowel disease is morbigenous.

Authors
  • Sawada, Koji
  • Takahashi, Ryouki
  • Saniabadi, Abbi R
  • Ohdo, Maiko
  • Shimoyama, Takashi
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Mar 14, 2006
Volume
12
Issue
10
Pages
1621–1625
Identifiers
PMID: 16570358
Source
Medline
License
Unknown

Abstract

Elevated CF in active IBD appears to be morbigenous. CF promotes IBD via two main mechanisms, quenching of TI (an anti-inflammatory substance) and impairing microvascular perfusion by forming protein aggregates. CF may also serve as a biomarker of chronic IBD. Additional studies are warranted to fully evaluate the role of CF in IBD and the outcome should contribute to a better understanding of the pathogenesis of IBD.

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