Affordable Access

Access to the full text

Elevated non-high-density lipoprotein cholesterol corresponds to a high risk of nephrolithiasis in children

Authors
  • Chen, Meiyuan1
  • Xiao, Jing1
  • Du, Yuan1
  • Wang, Miaomiao1
  • Ruan, Jimeng1
  • Tian, Ye1
  • 1 Beijing Friendship Hospital Affiliated to the Capital Medical University, No. 95, Yong’an Road, Xicheng District, Beijing, 100050, China , Beijing (China)
Type
Published Article
Journal
BMC Urology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Aug 10, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12894-020-00691-6
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundDyslipidemia contributes to the development of nephrolithiasis in adults; however its relationship to urolithiasis in children remains debatable, and will be clarified in the present work.MethodsA case–control study was performed involving 58 pediatric patients diagnosed with upper urinary tract stones as well as 351 controls. Age, gender, body mass index (BMI), serum calcium, serum uric acid, blood glucose, blood lipids, and compositions of stones were compared.ResultsAccording to the univariate analysis, uric acid was higher (P < 0.01) but serum calcium lower in the stone group than the control (P < 0.05). As for the blood lipids, non-high-density lipoprotein cholesterol (non-HDL-c) was significantly higher in the stone group as compared to the control (P < 0.01), while total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol did not show statistical difference between the two groups. In the multivariate analysis, only non-HDL-c and serum uric acid were increased in the stone group (P = 0.003 and P = 0.008). In the stone compositions’ analysis, serum uric acid and non-HDL-c were associated with percentage of uric acid and pure calcium oxalate stones, respectively.ConclusionNon-high-density lipoprotein cholesterol may act as a lipid risk factor for urolithiasis in children.

Report this publication

Statistics

Seen <100 times