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Elevated levels of high-mobility group box-1 (HMGB1) in patients with severe or uncomplicated Plasmodium falciparum malaria.

Authors
  • Angeletti, Davide1
  • Kiwuwa, Mpungu Steven
  • Byarugaba, Justus
  • Kironde, Fred
  • Wahlgren, Mats
  • 1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. [email protected] , (Sweden)
Type
Published Article
Journal
American Journal of Tropical Medicine and Hygiene
Publisher
American Society of Tropical Medicine and Hygiene
Publication Date
Apr 01, 2013
Volume
88
Issue
4
Pages
733–735
Identifiers
DOI: 10.4269/ajtmh.12-0530
PMID: 23400574
Source
Medline
License
Unknown

Abstract

Severe malaria is characterized by a massive release of proinflammatory cytokines in the context of sequestration of parasitized and normal red cells (RBCs). High-mobility group box 1 (HMGB1) is a DNA- and heparin-binding protein that also acts as a cytokine when released from cells in the extracellular milieu after a proinflammatory stimulus. In this study, we have measured the circulating levels of HMGB1 in 76 children with severe or uncomplicated malaria. Sera from both severe (P = 0.0022) and uncomplicated (P = 0.0049) patients had significantly higher circulating HMGB1 levels compared with healthy controls. Elevated HMGB1 in patients with ongoing Plasmodium falciparum infections might prolong inflammation and the febrile state of malaria and could offer a potential target for therapeutic intervention.

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