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Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice.

Authors
  • Sasaki, Takaaki
  • Watanabe, Wataru
  • Muranishi, Yuki
  • Kanamoto, Takashi
  • Aihara, Makoto
  • Miyazaki, Kazuko
  • Tamura, Hiroki
  • Saeki, Tadashiro
  • Oda, Hideaki
  • Souchelnytskyi, Nazariy
  • Souchelnytskyi, Serhiy
  • Aoyama, Hirohiko
  • Honda, Zen-ichiro
  • Furukawa, Takahisa
  • Mishima, Hiromu K
  • Kiuchi, Yoshiaki
  • Honda, Hiroaki
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Jan 01, 2009
Volume
50
Issue
1
Pages
242–248
Identifiers
DOI: 10.1167/iovs.08-2206
PMID: 18791169
Source
Medline
License
Unknown

Abstract

Deregulated expression of ODAG in the eye induces elevated intraocular pressure and optic nerve atrophy and impairs retinal development, possibly by interfering with the Rab6/Rab6-GAP-mediated signaling pathway. These results provide new insights into the mechanisms regulating ocular development, and ODAG Tg would be a novel animal model for human diseases caused by ocular hypertension.

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