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Elevated Expression and Genetic Association Links the SOCS3 Gene to Atopic Dermatitis

Authors
  • E. Ekelund
  • A. Sääf
  • M. Tengvall-Linder
  • E. Melen
  • J. Link
  • J. Barker
  • N. J. Reynolds
  • S. J. Meggitt
  • J. Kere
  • C.-F. Wahlgren
  • G. Pershagen
  • M. Wickman
  • M. Nordenskjöld
  • I. Kockum
  • M. Bradley
Publisher
The American Society of Human Genetics
Publication Date
Apr 14, 2006
Source
PMC
Keywords
Disciplines
  • Biology
  • Chemistry
  • Medicine
License
Unknown

Abstract

In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.

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