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Elevated corticosteroid levels block the memory-improving effects of nootropics and cholinomimetics.

Authors
Type
Published Article
Journal
Psychopharmacology
Publication Date
Volume
108
Issue
1-2
Pages
11–15
Identifiers
PMID: 1410129
Source
Medline
License
Unknown

Abstract

Oral pretreatment of mice with aldosterone or corticosterone blocked the memory-enhancing effects of piracetam, pramiracetam, aniracetam and oxiracetam in a dose-related manner, without, however, impairing the animals' learning performance. The improvement of memory induced by physostigmine, arecoline, and tacrine (THA) was similarly inhibited. The fact that elevated steroid levels suppress the memory-enhancing effects of entirely different substances could indicate that these substances have a common site of action. In the light of new observations showing increased cortisol concentrations in Alzheimer patients, this steroid dependency of the effects of memory enhancers might explain why only a limited number of these patients respond to therapy with nootropics or cholinomimetics.

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