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Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors.

Authors
  • Nagaya, N
  • Uematsu, M
  • Kojima, M
  • Date, Y
  • Nakazato, M
  • Okumura, H
  • Hosoda, H
  • Shimizu, W
  • Yamagishi, M
  • Oya, H
  • Koh, H
  • Yutani, C
  • Kangawa, K
Type
Published Article
Journal
Circulation
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Oct 23, 2001
Volume
104
Issue
17
Pages
2034–2038
Identifiers
PMID: 11673342
Source
Medline
License
Unknown

Abstract

Plasma ghrelin was elevated in cachectic patients with CHF, associated with increases in GH and TNF-alpha and a decrease in body mass index. Considering ghrelin-induced positive energy effects, increased ghrelin may represent a compensatory mechanism under catabolic-anabolic imbalance in cachectic patients with CHF.

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