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Elevated antibody to D-alanyl lipoteichoic acid indicates caries experience associated with fluoride and gingival health

Authors
  • Levine, Martin1
  • Brumley, Robert L1, 2
  • Avery, Kevin T3
  • Owen, Willis L4
  • Parker, Donald E4
  • 1 University of Oklahoma Health Sciences Center, Department of Biochemistry and Molecular Biology, Oklahoma City, OK, 73190, USA , Oklahoma City (United States)
  • 2 GenSys Technologies Inc., 9155 Little Farm Dr, White Lake, MI, 48386 , White Lake
  • 3 University of Oklahoma Health Sciences Center, Department of Community Dentistry, Oklahoma City, OK, 73190, USA , Oklahoma City (United States)
  • 4 University of Oklahoma Health Sciences Center, Department of Biostatistics and Epidemiology, Oklahoma City, OK, 73190, USA , Oklahoma City (United States)
Type
Published Article
Journal
BMC Oral Health
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 12, 2002
Volume
2
Issue
1
Identifiers
DOI: 10.1186/1472-6831-2-2
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundAcidogenic, acid-tolerant bacteria induce dental caries and require D-alanyl glycerol lipoteichoic acid (D-alanyl LTA) on their cell surface. Because fluoride inhibits acid-mediated enamel demineralization, an elevated antibody response to D-alanyl LTA may indicate subjects with more acidogenic bacteria and, therefore, an association of DMFT with fluoride exposure and gingival health not apparent in low responders.MethodsCluster analysis was used to identify low antibody content. Within low and high responders (control and test subjects), the number of teeth that were decayed missing and filled (DMFT), or decayed only (DT) were regressed against fluoride exposure in the water supply and from dentrifice use. The latter was determined from gingival health: prevalences of plaque (PL) and bleeding on probing (BOP), and mean pocket depth (PD). Age was measured as a possible confounding cofactor.ResultsIn 35 high responders, DMFT associated with length of exposure to fluoridated water (F score), PL and BOP (R2 = 0.51, p < 0.001), whereas in 67 low D-ala-IgG responders, DMFT associated with PL, age, and PD (R2 = 0.26, p < 0.001). BOP correlated strongly with number of 7 7 decayed teeth (DT) in 54 high responders (R2 = 0.57, p < 0.001), but poorly in 97 low responders (R2 = 0.12, p < 0.001). The strength of the PD association with DMFT, or of BOP with DT, in high responders significantly differed from that in low responders (p < 0.05).ConclusionCaries associates with gingival health and fluoridated water exposure in high D-alanyl LTA antibody responders.

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