Affordable Access

deepdyve-link
Publisher Website

Electrospun wound dressing as a promising tool for the therapeutic delivery of ascorbic acid and caffeine.

Authors
  • Avizheh, Laya1, 2
  • Peirouvi, Tahmineh3
  • Diba, Kambiz4
  • Fathi-Azarbayjani, Anahita2, 5
  • 1 Student Research Committee, Urmia University of Medical sciences, Urmia, Iran. , (Iran)
  • 2 Department of Pharmaceutics, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. , (Iran)
  • 3 Department of Anatomical Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. , (Iran)
  • 4 Department of Parasitology & Mycology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. , (Iran)
  • 5 Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran. , (Iran)
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
Dec 01, 2019
Volume
10
Issue
12
Pages
757–767
Identifiers
DOI: 10.4155/tde-2019-0059
PMID: 31840563
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Aim: The aim of this work is to formulate a wound dressing for the delivery of ascorbic acid and caffeine. Method: A wound dressing was developed from electrospun nanofiber containing ascorbic acid and caffeine. In vitro drug release was performed at 25°C and 32°C. Wound healing activity of the nanofiber mats was tested in vivo using rat model with skin excision. Antifungal activity of the dressing was tested on Candida albicans using the disc diffusion method. Results & conclusion: Zone of inhibition was 6.7 mm for caffeine dressing; however, inhibition zone increased to 16.7 mm for samples containing both caffeine and ascorbic acid. Animals treated with ascorbic acid showed collagen deposition and very few fibroblast cells. Blood vessels and fibroblasts were increased in caffeine-loaded dressings compared with the ascorbic acid group. The findings of the present work suggest the benefits of topical ascorbic acid and caffeine for its high wound healing effects.

Report this publication

Statistics

Seen <100 times