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Electron density study of the anti-Alzheimer's disease drug donepezil from conventional x-ray data and invariom database application.

Authors
  • Luger, Peter
  • Weber, Manuela
  • Dittrich, Birger
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
Jul 01, 2012
Volume
4
Issue
11
Pages
1399–1407
Identifiers
DOI: 10.4155/fmc.12.85
PMID: 22857531
Source
Medline
License
Unknown

Abstract

The electron density of donepezil in the small-molecule crystal structure mimics the intermolecular interactions within the receptor site. Complementing steric properties with electronic information can be a valuable procedure in the examination of molecular recognition of systems with biological activity.

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