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Electrolyte metabolism in patients with periodic affective disorders during treatment with rubidium.

Authors
  • Jenner, F A
  • Lee, C R
  • Paschalis, C
  • Hill, S E
  • Burkinshaw, L
  • Jennings, G
Type
Published Article
Journal
Psychopharmacology
Publication Date
Jan 01, 1983
Volume
81
Issue
4
Pages
301–309
Identifiers
PMID: 6419259
Source
Medline
License
Unknown

Abstract

Five patients suffering from periodic affective disorders with short mood-cycles were treated with rubidium chloride, producing peak erythrocyte concentrations between 9 and 13 mmol/l. Loading with rubidium was associated with decreased total body potassium, but red-cell potassium was unchanged. Regular mood-cycling was disturbed, together with the associated body-weight changes. There was a slight extracellular "metabolic" acidosis. Electrolyte concentrations fluctuate abnormally in these patients, and two muscle biopsy specimens had very low potassium contents.

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