Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. Part 2.
- Published Article
The Journal of organic chemistry
- Publication Date
Mar 08, 2002
An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN-TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/11871914