Affordable Access

Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. Part 2.

Authors
  • Feroci, Marta
  • Inesi, Achille
  • Palombi, Laura
  • Sotgiu, Giovanni
Type
Published Article
Journal
The Journal of organic chemistry
Publication Date
Mar 08, 2002
Volume
67
Issue
5
Pages
1719–1721
Identifiers
PMID: 11871914
Source
Medline
License
Unknown

Abstract

An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN-TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.

Report this publication

Statistics

Seen <100 times