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Electroconvulsive therapy in the treatment of depression in a former ecstasy user.

Authors
  • Freudenmann, Roland W
  • Schönfeldt-Lecuona, Carlos
  • Spitzer, Manfred
  • Hermle, Leopold
  • Grön, Georg
Type
Published Article
Journal
Journal of Psychopharmacology
Publisher
SAGE Publications
Publication Date
Nov 01, 2006
Volume
20
Issue
6
Pages
860–862
Identifiers
PMID: 16891342
Source
Medline
License
Unknown

Abstract

Depression in former ecstasy users may not respond to selective serotonin reuptake inhibitors (SSRIs) possibly due to damaged serotonergic synapses following long-term heavy ecstasy use. We report findings in a patient suffering from MDMA-induced depression which was refractory to several antidepressive medications including selective noradrenergic reuptake inhibitor (SNRI) and SSRI. An add-on repeated bilateral electroconvulsive therapy (ECT) was able to achieve a stable remission of affective and cognitive symptoms with a follow-up of more than 1.5 years. Add-on ECT could be a treatment option in former ecstasy users with severe depressive disorders that fail to respond to SSRI and/or SNRI. Clinical trials are needed to evaluate further the usefulness of ECT in this patient group.

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