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Electrochemical quantification of some water soluble vitamins in commercial multi-vitamin using poly-amino acid caped by graphene quantum dots nanocomposite as dual signal amplification elements.

Authors
  • Shadjou, Nasrin1
  • Hasanzadeh, Mohammad2
  • Omari, Ali3
  • 1 Department of Nano Technology, Nano Technology Research Center, Faculty of Chemistry, Urmia University, Urmia 57154, Iran. , (Iran)
  • 2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran. Electronic address: [email protected] , (Iran)
  • 3 Department of Nano Technology, Nano Technology Research Center, Faculty of Chemistry, Urmia University, Urmia 57154, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran. , (Iran)
Type
Published Article
Journal
Analytical Biochemistry
Publisher
Elsevier
Publication Date
Dec 15, 2017
Volume
539
Pages
70–80
Identifiers
DOI: 10.1016/j.ab.2017.10.011
PMID: 29056522
Source
Medline
Keywords
License
Unknown

Abstract

Rapid analyses of some water soluble vitamins (Vitamin B2, B9, and C) in commercial multi vitamins could be routinely performed in analytical laboratories. This study reports on the electropolymerization of a low toxic and biocompatible polymer "poly aspartic acid-graphene quantum dots" as a novel strategy for surface modification of glassy carbon electrode and preparation a new interface for measurement of selected vitamins in commercial multi vitamins. Electrochemical deposition, as a well-controlled synthesis procedure, has been used for subsequently layer-by-layer preparation of graphene quantum dots nanostructures on a poly aspartic acid using cyclic voltammetry techniques in the regime of -1.5 to 2 V. The field emission scanning electron microscopy indicated immobilization of graphene quantum dots onto poly aspartic acid film. The modified electrode possessed as an effective electroactivity for detection of water soluble vitamins by using cyclic voltammetry, chronoamperometry and differential pulse voltammetry. Enhancement of peak currents is ascribed to the fast heterogeneous electron transfer kinetics that arise from the synergistic coupling between the excellent properties of poly aspartic acid as semiconducting polymer, graphene quantum dots as high density of edge plane sites and chemical modification. Under the optimized analysis conditions, the prepared sensor for detection of VB2, VB9, and VC showed a low limit of quantification 0.22, 0.1, 0.1 μM, respectively.

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