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Electrochemical assays for determination of H2O2 and prostate-specific antigen based on a nanocomposite consisting of CeO2 nanoparticle-decorated MnO2 nanospheres

Authors
  • Dai, Yuxue1
  • Wang, Xueying1
  • Zhu, Xiaodong1
  • Liu, Hao1
  • Wang, Pengfei1
  • Wang, Ximei1
  • Zhang, Shaohua1
  • Sun, Yuanling1
  • Gao, Dandan1
  • Han, Rui1
  • Luo, Chuannan1
  • 1 University of Jinan, Jinan, 250022, People’s Republic of China , Jinan (China)
Type
Published Article
Journal
Microchimica Acta
Publisher
Springer-Verlag
Publication Date
Jul 06, 2020
Volume
187
Issue
8
Identifiers
DOI: 10.1007/s00604-020-04403-7
Source
Springer Nature
Keywords
License
Yellow

Abstract

A nanocomposite consisting of CeO2 nanoparticle-decorated MnO2 nanospheres ([email protected]) was synthesized for the first time via a hydrothermal method. [email protected] was exploited to construct an electrochemical assays for detecting H2O2 and prostate-specific antigen (PSA) with square wave voltammetry (SWV). The electrochemical results proved that [email protected] owned a better electrocatalytic effect towards H2O2 reduction than pure MnO2 NS and CeO2 NP due to the synergistic effect between MnO2 NS and CeO2 NP. Under optimized conditions, [email protected] assay can be applied to detect H2O2 in the range 1 to 3.0 × 103 μmol L−1. The label-free electrochemical immunoassay based on [email protected] displayed linearly with concentrations of PSA from 0.005 to 50.0 ng mL−1. The electrochemical assays also possessed acceptable sensitivity, selectivity, and stability. The study showed that [email protected] hold great potential as a biosensing platform and the clinical determination of tumor markers in human serum. Graphical abstractA nanocomposite consisting of CeO2 nanoparticles decorated MnO2 nanospheres (CeO2 @MnO2) was firstly synthesized via a hydrothermal method. [email protected] was firstly exploited to construct electrochemical assays for detecting H2O2 and prostate-specific antigen (PSA) with square wave voltammetry (SWV), respectively. The electrochemical results proved that [email protected] owned better electrocatalysis towards H2O2 reduction than pure MnO2 NS and CeO2 NP due to the synergistic effect between MnO2 NS and CeO2 NP. Under optimized conditions, [email protected] based assay relative to the H2O2 system can be applied to detect H2O2 with range from 1 to 3.0 × 103 μmol L−1. The label-free electrochemical immunoassay based on [email protected] relative to the H2O2 system displayed linearly with concentrations of PSA from 0.005 to 50.0 ng mL−1. The electrochemical assays also possessed acceptable sensitivity, selectivity and stability. The study showed that [email protected] hold great potential for biosensing platform and the clinic determination of tumor markers in human serum.

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