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Electrochemical Analysis of Sulfisoxazole Using Glassy Carbon Electrode (GCE) and MWCNTs/Rare Earth Oxide (CeO2 and Yb2O3) Modified-GCE Sensors

Authors
  • el-azazy;, marwa
Publication Date
Mar 21, 2022
Identifiers
DOI: 10.3390/molecules27062033
OAI: oai:mdpi.com:/1420-3049/27/6/2033/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

In this work, new electrochemical sensors based on the modification of glassy carbon electrode (GCE) with multiwalled carbon nanotubes (MWCNTs)—rare metal oxides (REMO) nanocomposites were fabricated by drop-to-drop method of MWCNTs-REMO dispersion in ethanol. REMO nanoparticles were synthesized by precipitation followed by hydrothermal treatment at 180 °C in absence and presence of TritonTM X-100 surfactant. Cyclic voltammetry (CV) analysis using [email protected] and [email protected] sensors were used for the analysis of sulfisoxazole (SFX) drug in water samples. The results of CV analysis showed that [email protected] sensors have up to 40-fold higher sensitivity with CeO2 compared to the bare GCE sensor. The estimated values of the limit of detection (LoD) of this electrochemical sensing using [email protected] and [email protected] electrodes reached 0.4 and 0.7 μM SFX in phosphate buffer pH = 7, respectively. These findings indicate that [email protected] electrodes are potential sensors for analysis of sulfonamide drugs in water and biological samples.

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