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Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study.

Authors
  • Schmittner, John
  • Schroeder, Jennifer R
  • Epstein, David H
  • Krantz, Mori J
  • Eid, Nicole C
  • Preston, Kenzie L
Type
Published Article
Journal
Pharmacotherapy
Publication Date
May 01, 2009
Volume
29
Issue
5
Pages
495–502
Identifiers
DOI: 10.1592/phco.29.5.495
PMID: 19397459
Source
Medline
License
Unknown

Abstract

Our preliminary data suggest that coadministration of lofexidine and methadone induces QTc interval prolongation. This drug combination should be prescribed cautiously, with ECG monitoring. Furthermore, because the participants with the largest changes in QTc interval in our study were female, women may be at highest risk.

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