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Electroacupuncture on the Scalp over the Motor Cortex Ameliorates Behavioral Deficits Following Neonatal Hypoxia-Ischemia in Rats via the Activation of Neural Stem Cells

Authors
  • Jung, Da Hee1, 2
  • Pak, Malk Eun1, 2
  • Lee, Hong Ju1, 2
  • Ahn, Sung Min
  • Yun, Young Ju
  • Shin, Yong-Il
  • Shin, Hwa Kyoung1, 2,
  • Lee, Seo-Yeon3
  • Choi, Byung Tae1, 2,
  • 1 (H.K.S.)
  • 2 Graduate Training Program of Korean Medicine for Healthy-Aging, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 50612, Korea
  • 3 Department of Pharmacology, Wonkwang University School of Medicine, Iksan 54538, Jeonbuk, Korea
Type
Published Article
Journal
Life
Publisher
MDPI
Publication Date
Oct 14, 2020
Volume
10
Issue
10
Identifiers
DOI: 10.3390/life10100240
PMID: 33066563
PMCID: PMC7602251
Source
PubMed Central
Keywords
License
Green

Abstract

Electroacupuncture (EA) therapy via alternating current stimulation on the scalp over the motor cortex is used for the treatment of brain disorders. Perinatal hypoxia-ischemia (HI), a brain injury in newborns, leads to long-term neurologic complications. Here, we investigated whether EA could promote functional improvements and neurogenesis in a neonatal HI rat model. A neonatal HI rat model was induced by permanent ligation of the left carotid artery in postnatal day 7 pups. EA for neonatal HI rats was performed at 2 Hz (1, 3, or 5 mA; 20 min) from 4–6 weeks after birth. HI rats undergoing EA had improved motor and memory function, with the greatest improvement after 3 mA EA. The corpus callosum was significantly thicker and showed a significant increase in proliferating astrocytes in the 3 mA EA group. We observed proliferating cells and a greater number of newly developed neurons and astrocytes in the subventricular zone and dentate gyrus of the 3 mA EA group than in those of the HI group. These results suggest that EA promotes functional improvements following neonatal HI assault via the proliferation and differentiation of neural stem cells. This effect was the strongest after 3 mA EA, suggesting that this is the optimal treatment dose.

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