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Elastometry of clot phantoms via magnetomotive ultrasound-based resonant acoustic spectroscopy

Authors
  • Levy, Benjamin E
  • Oldenburg, Amy L
Type
Published Article
Journal
Physics in Medicine and Biology
Publisher
IOP Publishing
Publication Date
Jul 21, 2022
Volume
67
Issue
15
Identifiers
DOI: 10.1088/1361-6560/ac7ea5
Source
ioppublishing
Keywords
Disciplines
  • Paper
License
Unknown

Abstract

Objective. An ultrasound-based system capable of both imaging thrombi against a dark field and performing quantitative elastometry could allow for fast and cost-effective thrombosis diagnosis, staging, and treatment monitoring. This study investigates a contrast-enhanced approach for measuring the Young’s moduli of thrombus-mimicking phantoms. Approach. Magnetomotive ultrasound (MMUS) has shown promise for lending specific contrast to thrombi by applying a temporally modulated force to magnetic nanoparticle (MNP) contrast agents and measuring resulting tissue displacements. However, quantitative elastometry has not yet been demonstrated in MMUS, largely due to difficulties inherent in measuring applied magnetic forces and MNP densities. To avoid these issues, in this work magnetomotive resonant acoustic spectroscopy (MRAS) is demonstrated for the first time in ultrasound. Main results. The resonance frequencies of gelatin thrombus-mimicking phantoms are shown to agree within one standard deviation with finite element simulations over a range of phantom sizes and Young’s moduli with less than 16% error. Then, in a proof-of-concept study, the Young’s moduli of three phantoms are measured using MRAS and are shown to agree with independent compression testing results. Significance. The MRAS results were sufficiently precise to differentiate between thrombus phantoms with clinically relevant Young’s moduli. These findings demonstrate that MRAS has potential for thrombus staging.

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