Affordable Access

Eicosapentaenoic Acid Improves Hepatic Metabolism and Reduces Inflammation Independent of Obesity in High-Fat-Fed Mice and in HepG2 Cells

Authors
  • Albracht-Schulte, Kembra
  • Gonzalez, Samantha
  • Jackson, Abigail
  • Wilson, Savanna
  • Ramalingam, Latha
  • Kalupahana, Nishan S.
  • Moustaid-Moussa, Naima
Publication Date
Mar 12, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

) gene expression. Accordingly, EPA also significantly reduced FASN and ACACA mRNAs in human HepG2 cells. Glycolysis, estimated by extracellular acidification rate, was significantly reduced in HepG2 cells treated with EPA vs. vehicle. Furthermore, we identified several miRNAs that are regulated by EPA in mouse liver, including miR-19b-3p, miR-21a-5p, and others, which target lipid metabolism and inflammatory pathways. In conclusion, our findings provide novel mechanistic evidence for beneficial effects of EPA in NAFLD, through the identification of specific genes and miRNAs, which may be further exploited as future NAFLD therapies.

Report this publication

Statistics

Seen <100 times