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Eicosanoids in tumor progression and metastasis.

Authors
Type
Published Article
Journal
Sub-cellular biochemistry
Publication Date
Volume
49
Pages
145–168
Identifiers
DOI: 10.1007/978-1-4020-8831-5_6
PMID: 18751911
Source
Medline

Abstract

Eicosanoids and the enzymes responsible for their generation in living systems are involved in the mediation of multiple physiological and pathophysiological responses. These bioactive metabolites are part of complex cascades that initiate and perpetuate several disease processes such as atherosclerosis, arthritis, neurodegenerative conditions, and cancer. The intricate role played by each of these metabolites in the initiation, progression, and metastasis of solid tumors has been a subject of intense research in the scientific community. This review summarizes some of the key aspects of eicasonoids and the associated enzymes, and the pathways they mediate in promoting tumor progression and metastasis.

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