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EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2

Authors
  • Shen, Ting1, 2
  • Guo, Qiang1, 2
  • 1 Kunming University of Science and Technology, China , (China)
  • 2 The First People's Hospital of Yunnan Province, China , (China)
Type
Published Article
Journal
Cell Biology International
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 11, 2019
Volume
44
Issue
1
Pages
2–13
Identifiers
DOI: 10.1002/cbin.11209
PMID: 31368612
PMCID: PMC6973235
Source
PubMed Central
Keywords
Disciplines
  • Reviews
License
Unknown
External links

Abstract

Proline‐rich tyrosine kinase 2 (Pyk2) is a member of focal adhesion kinase (FAK) non‐receptor tyrosine kinase family and has been found to promote cancer cell survival, proliferation, migration, invasion, and metastasis. Pyk2 takes part in different carcinogenic signaling pathways to promote cancer progression, including epidermal growth factor receptor (EGFR) signaling pathway. EGFR signaling pathway is a traditional carcinogenic signaling pathway, which plays a critical role in tumorigenesis and tumor progression. FAK inhibitors have been reported to fail to get the ideal anti‐cancer outcomes because of activation of EGFR signaling pathway. Better understanding of Pyk2 downstream targets and interconnectivity between Pyk2 and carcinogenic EGFR signaling pathway will help finding more effective targets for clinical anti‐cancer combination therapies. Thus, the interconnectivity between Pyk2 and EGFR signaling pathway, which regulates tumor development and metastasis, needs to be elucidated. In this review, we summarized the downstream targets of Pyk2 in cancers, focused on the connection between Pyk2 and EGFR signaling pathway in different cancer types, and provided a new overview of the roles of Pyk2 in EGFR signaling pathway and cancer development.

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