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EGF-stimulated migration in ovarian cancer cells is associated with decreased internalization, increased surface expression, and increased shedding of the urokinase plasminogen activator receptor.

Authors
  • Henic, Emir
  • Sixt, Michael
  • Hansson, Stefan
  • Høyer-Hansen, Gunilla
  • Casslén, Bertil
Type
Published Article
Journal
Gynecologic oncology
Publication Date
Apr 01, 2006
Volume
101
Issue
1
Pages
28–39
Identifiers
PMID: 16263158
Source
Medline
License
Unknown

Abstract

Increased cell surface uPAR in response to EGF stimulation results from mobilization of uPAR from detergent-resistant domains, increased expression of uPAR mRNA, and decreased internalization and degradation of uPAR. Both the anti-uPAR antibody R3, which inhibits binding of uPA, and the EGFR phosphorylation inhibitor Iressa inhibited cell migration in response to uPA as well as to EGF, suggesting that EGFR and uPAR are engaged in the same multiprotein assembly on the cell surface.

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