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Efficient synthesis of lactosaminylated core-2 O-glycans.

Authors
  • Misra, A K
  • Fukuda, M
  • Hindsgaul, O
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Oct 22, 2001
Volume
11
Issue
20
Pages
2667–2669
Identifiers
PMID: 11591497
Source
Medline
License
Unknown

Abstract

A series of lactosaminylated oligosaccharides found in mucin type O-glycans was synthesized using a generalized block strategy. The synthesis involved the addition of a protected lactosamine donor to a partially protected T-disaccharide derivative. The nonreducing galactose residues of the deblocked oligosaccharide products could be removed by beta-galactosidase from jack bean to produce the corresponding GlcNAc terminated compounds. A series of tri- to hexasaccharides was thus efficiently produced.

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