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Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays.

Authors
  • Praneenararat, Thanit1
  • Geske, Grant D
  • Blackwell, Helen E
  • 1 Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1322, USA.
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Oct 15, 2009
Volume
11
Issue
20
Pages
4600–4603
Identifiers
DOI: 10.1021/ol901871y
PMID: 19743816
Source
Medline
License
Unknown

Abstract

A method for the synthesis of small molecule macroarrays of N-acylated L-homoserine lactones (AHLs) is reported. A focused library of AHLs was constructed, and the macroarray platform was found to be compatible with both solution and agar-overlay assays using quorum-sensing (QS) reporter strains. Several QS antagonists were discovered and serve to showcase the macroarray as a straightforward technique for QS research.

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