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An Efficient Synthesis of 2-CF3-3-Benzylindoles

Authors
  • muzalevskiy, vasiliy m.
  • sizova, zoia a.
  • nenajdenko, valentine g.
Publication Date
Aug 22, 2021
Identifiers
DOI: 10.3390/molecules26165084
OAI: oai:mdpi.com:/1420-3049/26/16/5084/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

The reaction of α-CF3-β-(2-nitroaryl) enamines with benzaldehydes afforded effectively α,β-diaryl-CF3-enones having nitro group. Subsequent reduction of nitro group by NH4HCO2-Pd/C system initiated intramolecular cyclization to give 2-CF3-3-benzylindoles. Target products can be prepared in up to quantitative yields. Broad synthetic scope of the reaction was shown. Probable mechanism of indole formation is proposed.

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