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Efficient protection from methotrexate toxicity and selection of transduced human hematopoietic cells following gene transfer of dihydrofolate reductase mutants.

Authors
Type
Published Article
Journal
Experimental Hematology
0301-472X
Publisher
Elsevier
Publication Date
Volume
31
Issue
12
Pages
1215–1222
Identifiers
PMID: 14662327
Source
Medline

Abstract

Gene transfer of DHFR using suitable retroviral backbones and DHFR mutants significantly increases MTX resistance of human CFU-C and allows efficient in vitro selection of transduced cells using a short-term selection procedure.

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