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Efficient neutralization of primary isolates by the plasma from HIV-1 infected Indian children.

Authors
  • Prakash, S S1
  • Chaudhary, Alok Kumar
  • Lodha, Rakesh
  • Kabra, S K
  • Vajpayee, Madhu
  • Hazarika, Anjali
  • Bagga, Barun
  • Luthra, Kalpana
  • 1 Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India. , (India)
Type
Published Article
Journal
Viral Immunology
Publisher
Mary Ann Liebert
Publication Date
Oct 01, 2011
Volume
24
Issue
5
Pages
409–413
Identifiers
DOI: 10.1089/vim.2011.0028
PMID: 22004138
Source
Medline
License
Unknown

Abstract

We tested the plasma of 51 HIV-1-infected children (23 naïve and 28 ART treated) for neutralization against five primary isolates (PIs) generated from adult Indian HIV-1-infected patients. The plasma exhibited neutralization potential with significantly higher neutralizing antibody titers in ART-treated children than naïve children against three out of five PIs (p<0.0001). Further, in treated children, neutralizing antibody titers were higher in those children with suppressed viremia (<1000 RNA copies/mL) than non-suppressors against two of the three PIs. We report here for the first time the neutralization potential of the plasma of HIV-1-infected Indian children.

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