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Efficient asymmetric hydrogenation of α-acetamidocinnamates through a simple, readily available monodentate chiral H-phosphinate.

Authors
Type
Published Article
Journal
Chemistry - A European Journal
1521-3765
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
20
Issue
13
Pages
3631–3635
Identifiers
DOI: 10.1002/chem.201304675
PMID: 24615995
Source
Medline
Keywords
License
Unknown

Abstract

An air-stable, simple (R(P))-mentylbenzylphosphinate, readily available in large quantities, can efficiently induce the rhodium-catalyzed asymmetric hydrogenation of α-acetamidocinnamates with high enantioselectivity (up to 99.6% ee). Intramolecular hydrogen bonding plays an important role in this asymmetric induction.

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