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Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vector.

Authors
  • Miyagi, Naoto1
  • Rao, Vinay P
  • Ricci, Davide
  • Du, Zeji
  • Byrne, Guerard W
  • Bailey, Kent R
  • Nakai, Hiroyuki
  • Russell, Stephen J
  • McGregor, Christopher G A
  • 1 William J. von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA.
Type
Published Article
Journal
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Publication Date
May 2008
Volume
27
Issue
5
Pages
554–560
Identifiers
DOI: 10.1016/j.healun.2008.01.025
PMID: 18442723
Source
Medline
License
Unknown

Abstract

Our findings demonstrate efficient and durable rAAV9-mediated gene transfer to the transplanted heart after ex vivo perfusion and suggest that AAV9 is a promising vector for cardiac gene therapy.

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