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Efficiency of different decalcification protocols for nasal osseous structures in a rat experimental model of allergic rhinitis, and their effects on epithelial histology: an attempt at standardization.

Authors
  • Guibas, George V1
  • Lakis, Sotiris2
  • Gkimpas, Christoforos3
  • Manda, Marianthi3
  • Kapoukranidou, Dorothea4
  • Spandou, Evangelia3
  • 1 Allergy Department, 2nd Pediatric Clinic, University of Athens, Greece; Laboratory of Experimental Physiology, Aristotle University of Thessaloniki, Greece. Electronic address: [email protected] , (Greece)
  • 2 Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, Greece. , (Greece)
  • 3 Laboratory of Experimental Physiology, Aristotle University of Thessaloniki, Greece. , (Greece)
  • 4 Laboratory of Physiology, Aristotle University of Thessaloniki, Greece. , (Greece)
Type
Published Article
Journal
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
Publication Date
Dec 01, 2014
Volume
66
Issue
9-10
Pages
469–475
Identifiers
DOI: 10.1016/j.etp.2014.09.001
PMID: 25238695
Source
Medline
Keywords
License
Unknown

Abstract

EDTA treatment for 20 days is appropriate for decalcification of nasal structures in rat models of allergic rhinitis; further incubation preserves epithelial integrity but is not required. When urgency is a factor, formic-acid-based decalcification for 5 days yields acceptable results.

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