Affordable Access

[Efficacy of tumor necrosis factor-alpha blockade for severe sciatica?].

Authors
  • Genevay, Stéphane
  • Guerne, Pierre-André
  • Gabay, Cem
Type
Published Article
Journal
Revue médicale de la Suisse romande
Publication Date
Sep 01, 2004
Volume
124
Issue
9
Pages
543–545
Identifiers
PMID: 15552747
Source
Medline
License
Unknown

Abstract

The domain of sciatica is at the edge of a mini revolution. For ten years evidence have been accumulating in favour of a local inflammation rather than a pathology resulling only from a nerve compression. This hypothesis has first been strengthened by the discovery of inflammatory mediators in human herniated discs and then by animal models. These models have demonstrated the impossibility for nerve root compression to produce sciatica in the absence of inflammation and the importance of proinflammatory cytokines in this pathology. TNF-alpha have been proved to be the most important inflammatory cytokine and TNF-alpha modulators has been most effective in the treatment of these models. Two pilot studies realized on humans seem to confirm these experimental data. A multicenter randomised, double-blind, placebo controlled study is being planed in Switzerland.

Report this publication

Statistics

Seen <100 times