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Efficacy and safety of Guizhi-Shaoyao-Zhimu decoction in the treatment of rheumatoid arthritis

Authors
  • Ye, Jing1
  • Li, Renliang1
  • Hu, Ziyi2
  • Zhang, Ping1
  • Liu, Liangji2
  • 1 Jiangxi University of Traditional Chinese Medicine
  • 2 The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, P.R. China.
Type
Published Article
Journal
Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 05, 2021
Volume
100
Issue
9
Identifiers
DOI: 10.1097/MD.0000000000024416
PMID: 33655915
PMCID: PMC7939220
Source
PubMed Central
Keywords
Disciplines
  • Research Article
  • Study Protocol Systematic Review
License
Green

Abstract

Background: Rheumatoid arthritis (RA) is a significant public health problem associated with a substantial burden of functional disability. The Guizhi-Shaoyao-Zhimu decoction (GSZD), a traditional medicine, has been used in China for a long time to treat RA. This study aimed to systematically investigate the efficacy and safety of GSZD in the treatment of RA. Methods: We will search the electronic databases of PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, the Chongqing VIP Chinese Science and Technology Periodical Database, Wanfang Database, and China Biomedical Literature Database, and also manually search the Chinese Clinical Trial Register and unpublished studies or references, with the establishment up to February 2021. According to the inclusion and exclusion criteria, we will screen the literature, and the data are extracted independently by the 2 researchers. We will collect RCTs of GSZD in the treatment of RA. RevMan5.3 will be used for statistical analysis. According to the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE), we will appraise each outcome quality evidence. Results: We will publish the results in a peer-reviewed journal. Conclusion: We will evaluate the efficacy and safety of GSZD in treating RA. Unique INPLASY number: INPLASY2020120147.

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