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[Efficacy and safety of cefepime in the treatment of bronchopulmonary disease exacerbation in pediatric patients with mucoviscidosis].

Authors
  • Semykin, S Iu
  • Postnikov, S S
  • Polikarpova, S V
  • Dubovik, L G
  • Kolbatova, E S
Type
Published Article
Journal
Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR
Publication Date
Jan 01, 2005
Volume
50
Issue
4
Pages
18–22
Identifiers
PMID: 16392335
Source
Medline
License
Unknown

Abstract

Clinicobacteriological effect of cefepime (in combination with amikacin) was studies in 25 pediatric patients of the age of 7 to 17 years with a mixed form of mucoviscidosis at the stage of the bronchopulmonary infection exacerbation. The basic pathogens isolated from the sputum were: Pseudomonas aeruginosa sm., P. aeruginosa muc. (67.5%) and Staphylococcus aureus (29.1%). The 2-week treatment course resulted in a marked clinical effect with improvement of the lung functional indices and eradication of the majority of the S. aureus strains (81.2%) and half of the P. aeruginosa strains (49.6%). The only side effect was moderate diarrhea not requiring discontinuation of the drug use.

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